2022
Prices generally increase with newer model years (2023 > 2022 > 2021), with mileage decreasing for newer models. Depreciation appears relatively consistent across the 2021-2022 model years in this dataset.
Moderate
When looking for a Mercedes-Benz E-Class in this range, prioritize 2022 models for a good balance of price and mileage. While 2021 models are cheaper, they tend to have higher mileage. Consider cars with slightly higher mileage if the price savings are significant, but always review the maintenance history. Listings with longer days on market may offer more room for negotiation.
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W222 S 450 4MATIC
2018-2020
sedanW221 S 63 AMG
2008-2013
sedanW222 AMG S 65
2016-2020
sedanW212 (4th Gen) Facelift E 63 AMG
2014
sedanW220 S 430
2001-2005
sedanW212 (4th Gen) Facelift E 250 BlueTEC Luxury 4MATIC
2014
sedanLast analyzed: September 2, 2025